Most systemic viral gene therapies have been limited by sequestration and degradation of virions, innate and adaptive immunity, and silencing of therapeutic genes within the target cells. Here we ...

Recent studies have revealed that YKL-40 is involved in the pathogenesis of asthma. However, its specific mechanism remains unclear. The present study aims to investigate the effect of adenovirus ...

One of the more exciting opportunities in medical technology is using a virus to carry genetic information in the form of DNA and RNA in the cells. One of the most commonly used viruses is ...

Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of ...

ZENYTH-ESO: Master protocol to assess the safety and recommended phase II dose of next generation NY-ESO-1-specific TCR T-cells in HLA-A*02 patients with synovial sarcoma and myxoid/round cell ...

Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

The pandemic has further advanced this platform's use, since one of the frontrunner vaccines, now in phase 3 trials, is built on one such vector. Engineered Simian Adenoviral Vector The GRAd32 viral ...

A photo of a CanSino scientist holding a vial of its Ad5-based COVID-19 vaccine. CanSino Biologics began a clinical trial of its Ad5-based COVID-19 vaccine on March 16. Credit: CanSino Biologics ...

Validation Study of the Accuracy of a Postoperative Nomogram for Recurrence After Radical Prostatectomy for Localized Prostate Cancer RESULTS: Specific transgene expression was detected in tissues ...

VITT antibodies feature an oligoclonal or monoclonal antibody profile with a remarkable degree of clonal identity of the light chains, 3,4 which results in a strikingly similar structure of the ...