If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

A new study led by researchers at the University of Pittsburgh (Pitt) and UPMC Hillman Cancer Center has shown that an enzyme called PARP1 is involved in the repair of telomeres, the lengths of DNA ...

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...

Throughout the course of our lives, DNA can break in response to natural and environmental factors. However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors, ...